ABSTRACT
Objective To learn the prevalence and risk factors of depression among H -type hypertension patients and to provide suggestions for early intervention.Methods Self -rating depression scale(SDS)and self -designed general condition questionnaire were used to investigate the prevalence of depression,the risk factors of depression among H -type hypertension patients.The data were analyzed by univariate analysis and multivariate logistic regression analysis.Results A total of 458 patients who were admitted to our hospital from Jan,2013 to Jan,2014 were enrolled in this study.Of 458 patients,24.45%had depression.The prevalence among males was higher than females (29.81% vs 20.00%,P <0.05),and the prevalence increased with age (P <0.05).Univariate analysis showed that there were significant differences in age,gender,educational level,family support,complications,courses of disease,systematic therapy,economic conditions and family history of depression between patients with or without depression (P <0.05).Multivariate logistic regression analysis showed that gender (OR =1.99,95%CI =1.65 -2.38),educational level (OR =3.77,95%CI =2.93 -5.48)and courses of disease (OR =1.71,95%CI =1.54 -1.90)were independent risk factors of depression.Conclusion The prevalence of depression among H -type hypertension patients is at a high level.It is important to carry out comprehensive intervention for risk factors to prevent depression among patients with H -type hypertension.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the significance of clinicopathological stage of chronic idiopathic myelofibrosis (CIMF) in WHO classification of 2001.</p><p><b>METHODS</b>Histopathological analysis of bone marrow biopsy plastic-embedded sections stained with H-G-E and Gomori's stains and clinical features of 113 cases previously diagnosed as primary myelofibrosis (PMF) and 48 cases MPD-U (total of 161 cases which including male 79 and female 82) were studied retrospectively.</p><p><b>RESULTS</b>There was no significant differences on the clinical features among the cellular phase, collagen fiber phase, sclerotic phase and osteomyelosclerosis of 113 previously diagnosed patients. According to WHO classification 2001 of CIMF, previously diagnosis in 48 cases with MPD-U was WHO pre-CIMF, and in 113 cases with PMF was WHO CIMF-Fs. There were significant differences between of WHO pre-CIMF and WHO CIMF-Fs about clinicopathological features except age. The percentage of immature granulocytes, normoblasts, lymphocytes in peripheral blood, the size of hepatosplenomegaly, and the percent age of tear drop-like red blood cells in pre-CIMF were significantly lower than those in CIMF-Fs (P < 0.05). However, the number of hemoglobin and platelets in patients with pre-CIMF were significantly higher than that with CIMF-Fs (P < 0.01).</p><p><b>CONCLUSION</b>pre-CIMF and CIMF-Fs in clinical and histopathological features were different development stage of CIMF, while osteomyelosclerosis is a variant of CIMF, but not an independent disease.</p>